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Include the appropriate security policy in your API proxies, such as Verify API Key or OAuth v2.0. The API product uses API keys and/or OAuth access tokens to enforce API access. For more, see API keys and OAuth home.
Add API proxies and/or resource paths to your API product to restrict access. Otherwise, any app associated with the API product will be able to make calls to any API in your Edge organization.
IF you need step by step process, check out the Apigee tutorial.
if you need assistance check out the official docs.
To achieve synchronization between your Drupal portal and Apigee Edge for new API products, you can try this-
APIGEE Edge Setup:
Set up your API products in Apigee Edge, and make sure each API product has a clear name, description, and any required attributes.
Utilize Drupal's extensibility and API capabilities to achieve this synchronization. You can create a custom module or use existing modules to connect Drupal with Apigee. As per this msbi taining resource, the custom module has potential to connect Drupal with Apigee.